[HTML][HTML] Cellular characterization of a novel focal adhesion kinase inhibitor
JK Slack-Davis, KH Martin, RW Tilghman… - Journal of Biological …, 2007 - ASBMB
Focal adhesion kinase (FAK) is a member of a family of non-receptor protein-tyrosine
kinases that regulates integrin and growth factor signaling pathways involved in cell
migration, proliferation, and survival. FAK expression is increased in many cancers,
including breast and prostate cancer. Here we describe perturbation of adhesion-mediated
signaling with a FAK inhibitor, PF-573,228. In vitro, this compound inhibited purified
recombinant catalytic fragment of FAK with an IC 50 of 4 nm. In cultured cells, PF-573,228 …
kinases that regulates integrin and growth factor signaling pathways involved in cell
migration, proliferation, and survival. FAK expression is increased in many cancers,
including breast and prostate cancer. Here we describe perturbation of adhesion-mediated
signaling with a FAK inhibitor, PF-573,228. In vitro, this compound inhibited purified
recombinant catalytic fragment of FAK with an IC 50 of 4 nm. In cultured cells, PF-573,228 …