[HTML][HTML] Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length …
FTY720, a sphingosine analog, is in clinical trials as an immunomodulator. The biological
effects of FTY720 are believed to occur after its metabolism to FTY720 phosphate. However,
very little is known about whether FTY720 can interact with and modulate the activity of other
enzymes of sphingolipid metabolism. We examined the ability of FTY720 to modulate de
novo ceramide synthesis. In mammals, ceramide is synthesized by a family of six ceramide
synthases, each of which utilizes a restricted subset of acyl-CoAs. We show that FTY720 …
effects of FTY720 are believed to occur after its metabolism to FTY720 phosphate. However,
very little is known about whether FTY720 can interact with and modulate the activity of other
enzymes of sphingolipid metabolism. We examined the ability of FTY720 to modulate de
novo ceramide synthesis. In mammals, ceramide is synthesized by a family of six ceramide
synthases, each of which utilizes a restricted subset of acyl-CoAs. We show that FTY720 …