[HTML][HTML] Elucidating the chemical structure of native 1-deoxysphingosine [S]
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the
enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in
canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the
rare inherited neuropathy, HSAN1, and diabetes type 2 and might contribute to β cell failure
and the diabetic sensory neuropathy. In analogy to canonical sphingolipids, it was assumed
that 1-deoxySLs also bear a (4E) double bond, which is normally introduced by sphingolipid …
enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in
canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the
rare inherited neuropathy, HSAN1, and diabetes type 2 and might contribute to β cell failure
and the diabetic sensory neuropathy. In analogy to canonical sphingolipids, it was assumed
that 1-deoxySLs also bear a (4E) double bond, which is normally introduced by sphingolipid …