Context Despite reported success, surgery for pharmacoresistant seizures is often seen as a
last resort. Patients are typically referred for surgery after 20 years of seizures, often too late
to avoid significant disability and premature death. Objective We sought to determine
whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued
medical management in controlling seizures and improving quality of life (QOL). Design,
Setting, and Participants The Early Randomized Surgical Epilepsy Trial (ERSET) is a …