[HTML][HTML] Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms*♦
J Li, T Kanekiyo, M Shinohara, Y Zhang… - Journal of Biological …, 2012 - ASBMB
Aggregation of amyloid-β (Aβ) peptides leads to synaptic disruption and neurodegeneration
in Alzheimer disease (AD). A major Aβ clearance pathway in the brain is cellular uptake and
degradation. However, how Aβ traffics through the endocytic pathway and how AD risk
factors regulate this event is unclear. Here we show that the majority of endocytosed Aβ in
neurons traffics through early and late endosomes to the lysosomes for degradation.
Overexpression of Rab5 or Rab7, small GTPases that function in vesicle fusion for early and …
in Alzheimer disease (AD). A major Aβ clearance pathway in the brain is cellular uptake and
degradation. However, how Aβ traffics through the endocytic pathway and how AD risk
factors regulate this event is unclear. Here we show that the majority of endocytosed Aβ in
neurons traffics through early and late endosomes to the lysosomes for degradation.
Overexpression of Rab5 or Rab7, small GTPases that function in vesicle fusion for early and …