Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable
I Tindemans, M Lukkes, MJW de Bruijn, BWS Li… - Journal of Allergy and …, 2017 - Elsevier
Background Allergic asthma is characterized by a TH 2 response induced by dendritic cells
(DCs) that present inhaled allergen. Although the mechanisms by which they instruct TH 2
differentiation are still poorly understood, expression of the Notch ligand Jagged on DCs has
been implicated in this process. Objective We sought to establish whether Notch signaling
induced by DCs is critical for house dust mite (HDM)–driven allergic airway inflammation
(AAI) in vivo. Methods The induction of Notch ligand expression on DC subsets by HDM was …
(DCs) that present inhaled allergen. Although the mechanisms by which they instruct TH 2
differentiation are still poorly understood, expression of the Notch ligand Jagged on DCs has
been implicated in this process. Objective We sought to establish whether Notch signaling
induced by DCs is critical for house dust mite (HDM)–driven allergic airway inflammation
(AAI) in vivo. Methods The induction of Notch ligand expression on DC subsets by HDM was …