Background Exposure to traffic-related particulate matter promotes asthma and allergic
diseases. However, the precise cellular and molecular mechanisms by which particulate
matter exposure acts to mediate these effects remain unclear. Objective We sought to
elucidate the cellular targets and signaling pathways critical for augmentation of allergic
airway inflammation induced by ambient ultrafine particles (UFP). Methods We used in vitro
cell-culture assays with lung-derived antigen-presenting cells and allergen-specific T cells …