Diesel exhaust particle induction of IL-17A contributes to severe asthma
EB Brandt, MB Kovacic, GB Lee, AM Gibson… - Journal of Allergy and …, 2013 - Elsevier
Background IL-17A has been implicated in severe forms of asthma. However, the factors that
promote IL-17A production during the pathogenesis of severe asthma remain undefined.
Diesel exhaust particles (DEPs) are a major component of traffic-related air pollution and are
implicated in asthma pathogenesis and exacerbation. Objective We sought to determine the
mechanism by which DEP exposure affects asthma severity using human and mouse
studies. Methods BALB/c mice were challenged with DEPs with or without house dust mite …
promote IL-17A production during the pathogenesis of severe asthma remain undefined.
Diesel exhaust particles (DEPs) are a major component of traffic-related air pollution and are
implicated in asthma pathogenesis and exacerbation. Objective We sought to determine the
mechanism by which DEP exposure affects asthma severity using human and mouse
studies. Methods BALB/c mice were challenged with DEPs with or without house dust mite …