Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation
Y Nakamura, M Miyata, T Ohba, T Ando… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Both active and passive smoking are considered to be risk factors for
asthma development. However, the precise mechanisms involved remain elusive. Recently,
thymic stromal lymphopoietin (TSLP) has been shown to play a key role in the development
of TH2-type allergic inflammation in patients with asthma. OBJECTIVE: The aim of this study
was to investigate whether there was a causal relationship between cigarette smoke
exposure and TSLP expression in the lung. METHODS: We examined the effects of …
asthma development. However, the precise mechanisms involved remain elusive. Recently,
thymic stromal lymphopoietin (TSLP) has been shown to play a key role in the development
of TH2-type allergic inflammation in patients with asthma. OBJECTIVE: The aim of this study
was to investigate whether there was a causal relationship between cigarette smoke
exposure and TSLP expression in the lung. METHODS: We examined the effects of …