Parental tobacco smoking is associated with augmented IL-13 secretion in children with allergic asthma

W Feleszko, A Zawadzka-Krajewska, K Matysiak… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Exposure to environmental tobacco smoke (ETS) has been shown to
increase symptoms of allergic bronchial asthma, but direct effects on the expression of
inflammatory markers have not been demonstrated thus far. OBJECTIVE: The aim of this
study was to assess the correlation of ETS exposure with the expression of proinflammatory
mediators in airway secretions, including IFN-γ and IL-12, as well as IL-5 and IL-13, in
allergic asthmatic schoolchildren and healthy control subjects. METHODS: By using the …