Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells
JY Hong, JK Bentley, Y Chung, J Lei… - Journal of Allergy and …, 2014 - Elsevier
Background Early-life human rhinovirus infection has been linked to asthma development in
high-risk infants and children. Nevertheless, the role of rhinovirus infection in the initiation of
asthma remains unclear. Objective We hypothesized that, in contrast to infection of mature
BALB/c mice, neonatal infection with rhinovirus promotes an IL-25–driven type 2 response,
which causes persistent mucous metaplasia and airways hyperresponsiveness. Methods
Six-day-old and 8-week-old BALB/c mice were inoculated with sham HeLa cell lysate or …
high-risk infants and children. Nevertheless, the role of rhinovirus infection in the initiation of
asthma remains unclear. Objective We hypothesized that, in contrast to infection of mature
BALB/c mice, neonatal infection with rhinovirus promotes an IL-25–driven type 2 response,
which causes persistent mucous metaplasia and airways hyperresponsiveness. Methods
Six-day-old and 8-week-old BALB/c mice were inoculated with sham HeLa cell lysate or …