Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients
A Sykes, MR Edwards, J Macintyre… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Asthmatic patients have defective rhinovirus-induced IFN-β and IFN-λ
production from bronchial epithelial cells and IFN-λ from bronchoalveolar lavage (BAL) cells.
Whether bronchoalveolar lavage cells have defective type I interferon responses to
rhinovirus is unknown, as are mechanisms explaining defective rhinovirus interferon
induction in asthmatic patients. OBJECTIVE: We sought to investigate rhinovirus induction of
type I interferons in BAL and blood mononuclear cells from asthmatic patients and healthy …
production from bronchial epithelial cells and IFN-λ from bronchoalveolar lavage (BAL) cells.
Whether bronchoalveolar lavage cells have defective type I interferon responses to
rhinovirus is unknown, as are mechanisms explaining defective rhinovirus interferon
induction in asthmatic patients. OBJECTIVE: We sought to investigate rhinovirus induction of
type I interferons in BAL and blood mononuclear cells from asthmatic patients and healthy …