[HTML][HTML] Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin
MT Stier, MH Bloodworth, S Toki, DC Newcomb… - Journal of Allergy and …, 2016 - Elsevier
Background Respiratory syncytial virus (RSV) is a major health care burden with a
particularly high worldwide morbidity and mortality rate among infants. Data suggest that
severe RSV-associated illness is in part caused by immunopathology associated with a
robust type 2 response. Objective We sought to determine the capacity of RSV infection to
stimulate group 2 innate lymphoid cells (ILC2s) and the associated mechanism in a murine
model. Methods Wild-type (WT) BALB/c, thymic stromal lymphopoietin receptor (TSLPR) …
particularly high worldwide morbidity and mortality rate among infants. Data suggest that
severe RSV-associated illness is in part caused by immunopathology associated with a
robust type 2 response. Objective We sought to determine the capacity of RSV infection to
stimulate group 2 innate lymphoid cells (ILC2s) and the associated mechanism in a murine
model. Methods Wild-type (WT) BALB/c, thymic stromal lymphopoietin receptor (TSLPR) …