[HTML][HTML] HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration
Y Dong, Y Gu, Y Huan, Y Wang, Y Liu, M Liu… - Journal of Biological …, 2013 - ASBMB
Uncontrolled, excessive inflammation contributes to the secondary tissue damage of
traumatic spinal cord, and HMGB1 is highlighted for initiation of a vicious self-propagating
inflammatory circle by release from necrotic cells or immune cells. Several regenerative-
competent vertebrates have evolved to circumvent the second damages during the
spontaneous spinal cord regeneration with an unknown HMGB1 regulatory mechanism. By
genomic surveys, we have revealed that two paralogs of HMGB1 are broadly retained from …
traumatic spinal cord, and HMGB1 is highlighted for initiation of a vicious self-propagating
inflammatory circle by release from necrotic cells or immune cells. Several regenerative-
competent vertebrates have evolved to circumvent the second damages during the
spontaneous spinal cord regeneration with an unknown HMGB1 regulatory mechanism. By
genomic surveys, we have revealed that two paralogs of HMGB1 are broadly retained from …
