Lipids in biological membranes are organized non-randomly across the bilayer. In
eukaryotic cells, the cytoplasmic surface is enriched in anionic and primary amine-
containing phospholipids (phosphoinositides (PIPn), 2 phosphatidic acid,
phosphatidylethanolamine (PE), phosphatidylserine (PS)), whereas the extracytoplasmic
leaflet and the topologically equivalent lumenal surface of internal organelles are enriched
in choline-containing phospholipids (phosphatidylcholine (PC) and sphingomyelin) and …