Alzheimer's disease (AD) includes etiologically heterogenous disorders characterized by
senile or presenile dementia, extracellular amyloid protein aggregations containing an
insoluble amyloid precursor protein derivative, and intracytoplasmic tau protein
aggregations. Recent studies also show excess neuronal aneuploidy, programmed cell
death (PCD), and mitochondrial dysfunction. The leading AD molecular paradigm, the
“amyloid cascade hypothesis”, is based on studies of rare autosomal dominant variants and …