Preclinical frailty assessments: phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications
Use of different objective frailty assessment tools may improve understanding of the biology
of frailty and allow evaluation of effects of interventions on frailty. Polypharmacy is
associated with increased risk of frailty in epidemiologic studies, regardless of frailty
definition, but the pathophysiology of the association is not well understood. This study aims
to (1) assess and compare the prevalence of frailty from middle to old age following control,
chronic polypharmacy or monotherapy treatment, when measured using the clinical frailty …
of frailty and allow evaluation of effects of interventions on frailty. Polypharmacy is
associated with increased risk of frailty in epidemiologic studies, regardless of frailty
definition, but the pathophysiology of the association is not well understood. This study aims
to (1) assess and compare the prevalence of frailty from middle to old age following control,
chronic polypharmacy or monotherapy treatment, when measured using the clinical frailty …
