[HTML][HTML] SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation [S]
A Sané, L Ahmarani, E Delvin, N Auclair, S Spahis… - Journal of lipid …, 2019 - ASBMB
Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result
in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble
vitamins into the blood circulation. The central aim of this study is to test the hypothesis that
SAR1B deletion (SAR1B−/−) disturbs enterocyte lipid homeostasis (eg, FA β-oxidation and
lipogenesis) while promoting oxidative stress and inflammation. Another issue is to compare
the impact of SAR1B−/− to that of its paralogue SAR1A−/− and combined SAR1A−/−/B …
in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble
vitamins into the blood circulation. The central aim of this study is to test the hypothesis that
SAR1B deletion (SAR1B−/−) disturbs enterocyte lipid homeostasis (eg, FA β-oxidation and
lipogenesis) while promoting oxidative stress and inflammation. Another issue is to compare
the impact of SAR1B−/− to that of its paralogue SAR1A−/− and combined SAR1A−/−/B …
