Plus-maze retest profile in mice: importance of initial stages of trial 1 and response to post-trial cholinergic receptor blockade
RJ Rodgers, NJT Johnson, JC Cole, CV Dewar… - Pharmacology …, 1996 - Elsevier
Recent research has shown that a single undrugged prior experience of the elevated plus-
maze produces significant behavioural changes upon 24-h retest in rats and mice. Typically,
when reexposed to the maze, animals display an increased avoidance of the open arms and
a corresponding preference for the enclosed sections of the apparatus. Using ethological
analyses, the present series of experiments sought to further characterize this phenomenon
in mice and to determine whether or not it involves cholinergic receptor mechanisms …
maze produces significant behavioural changes upon 24-h retest in rats and mice. Typically,
when reexposed to the maze, animals display an increased avoidance of the open arms and
a corresponding preference for the enclosed sections of the apparatus. Using ethological
analyses, the present series of experiments sought to further characterize this phenomenon
in mice and to determine whether or not it involves cholinergic receptor mechanisms …
