According to the US Centers for Disease Control and Prevention (CDC), onequarter of reproductive-aged women (ie, 15–49 years of age) hospitalized with coronavirus disease 2019 (COVID-19) from March 1–August 22, 2020, were pregnant, and pregnant women were more likely to require mechanical ventilation than nonpregnant women (1). The CDC also reports that cisgender women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy are at higher risk for preterm birth (2). Gestation-associated physical, immunological, and endocrinological changes typically place pregnant women and their fetuses at greater risk for severe complications caused by infectious diseases, which is not unique to SARS-CoV-2 (3). Currently, all studies and references are for cisgender women, because there is a paucity of information on SARS-CoV-2 infection and vaccination during transgender pregnancies.