Histone chaperones, a supporting role in the limelight
A Loyola, G Almouzni - Biochimica et Biophysica Acta (BBA)-Gene …, 2004 - Elsevier
In eukaryotic cells, highly basic histone proteins are associated with the DNA to form the
nucleosome, the fundamental unit of chromatin. Histones are closely escorted by histone
chaperones from their point of synthesis up to their delivery site. We will present an overview
of the histone chaperones identified to date with their various roles, in an attempt to highlight
their importance in cellular metabolism. Nucleoplasmin will illustrate a role in histone
storage and Nap-1, a histone translocator. CAF-1 and Hira will provide examples of distinct …
nucleosome, the fundamental unit of chromatin. Histones are closely escorted by histone
chaperones from their point of synthesis up to their delivery site. We will present an overview
of the histone chaperones identified to date with their various roles, in an attempt to highlight
their importance in cellular metabolism. Nucleoplasmin will illustrate a role in histone
storage and Nap-1, a histone translocator. CAF-1 and Hira will provide examples of distinct …
